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Methotrexate renders an antitumor, immunosuppressive and cytotoxic action. The drug acts on the bone marrow cells of malignant tumors, embryonic cells, epithelial cells, bladder cells of the intestinal mucosa and oral cavity.

For adults and children aged 15 years Singulair can be applied as an auxiliary therapy of persistent asthma of different severity shapes, poorly controlled by inhaled corticosteroids or adrenergic agonists, as well as for the therapy of seasonal rhinitis of allergic origin for patients with bronchial asthma. Well as prevention of asthma attack, caused by physical exertion. The drug is taken perorally once a day regardless of meal. For bronchial asthma are appointed 4 mg at night.